Curcumin and the cellular stress response in free radical-related diseases

被引：133

作者：

Calabrese, Vittorio ^{[1
]}

Bates, Timothy E. ^{[2
]}

Mancuso, Cesare ^{[3
]}

Cornelius, Carolin

Ventimiglia, Bernardo ^{[4
]}

Cambria, Maria Teresa

Di Renzo, Laura ^{[5
]}

De Lorenzo, Antonino ^{[5
]}

Dinkova-Kostova, Albena T. ^{[6
,7
,8
]}

机构：

[1] Univ Catania, Dept Chem, Biochem & Mol Biol Sect, Clin Biochem & Clin Mol Biol Chair, I-95100 Catania, Italy

[2] Univ Nottingham, Sch Biomed Sci, Nottingham NG7 2RD, England

[3] Catholic Univ, Sch Med, Inst Pharmacol, Rome, Italy

[4] Univ Catania, Dept Sci Senescence Urol & Neurourol, Catania, Italy

[5] Univ Roma Tor Vergata, Dept Neurosci, Human Nutr Unit, Rome, Italy

[6] Johns Hopkins Univ, Sch Med, Div Clin Pharmacol, Dept Med & Pharmacol, Baltimore, MD USA

[7] Johns Hopkins Univ, Sch Med, Div Clin Pharmacol, Dept Mol Sci, Baltimore, MD USA

[8] Univ Dundee, Ninewells Hosp & Med Sch, Biomed Res Ctr, Dundee DD1 9SY, Scotland

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2008年 / 52卷 / 09期

关键词：

curcumin; free radicals; heat shock proteins; heme oxygenase; neurodegenerative disorders;

D O I：

10.1002/mnfr.200700316

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases.

引用

页码：1062 / 1073

页数：12

共 141 条

[1] Curcumin reduces cold storage-induced damage in human cardiac myoblasts [J].