Metal ions and prion diseases

被引：106

作者：

Lehmann, S ^{[1
]}

机构：

[1] CNRS UPR 1142, Inst Genet Humaine, F-34396 Montpellier 5, France

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(02)00295-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent data demonstrate that transition metal ions such as copper not only bind the priors protein with high affinities, but also modify its biochemical properties. This has important consequences for the potential function of the protein in metal-ion transport or as an anti-oxidant molecule. In addition, this relationship between the priors protein and metal ions is likely to play a critical role in the physiopathology of priors diseases.

引用

页码：187 / 192

页数：6

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