Hepatocellular transport and secretion of biliary lipids

被引:39
作者
Cohen, DE
机构
[1] Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Med, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Biochem, Bronx, NY 10461 USA
关键词
D O I
10.1097/00041433-199908000-00002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bile is the route for elimination of cholesterol from the body. Recent studies have begun to elucidate hepatocellular, molecular and physical-chemical mechanisms whereby bile salts stimulate biliary secretion of cholesterol together with phospholipids, which are enriched (up to 95%) in phosphatidylcholines. Active translocation of bile salts and phosphatidylcholines across the hepatocyte's canalicular plasma membrane provides the driving force for biliary lipid secretion. This facilitates physical-chemical interactions between detergent-like bile salt molecules and the ectoplasmic leaflet of the canalicular membrane, which result in biliary secretion of cholesterol and phosphatidylcholines as vesicles. Within the hepatocyte, separate molecular pathways function to resupply bile salts, phosphatidylcholines and cholesterol to the canalicular membrane for ongoing biliary lipid secretion. Curr Opin Lipidol 10:295-302. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:295 / 302
页数:8
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