Vacuolar H+-ATPase:: functional mechanisms and potential as a target for cancer chemotherapy

被引：41

作者：

Torigoe, T ^{[1
]}

Izumi, H ^{[1
]}

Ise, T ^{[1
]}

Murakami, T ^{[1
]}

Uramoto, H ^{[1
]}

Ishiguchi, H ^{[1
]}

Yoshida, Y ^{[1
]}

Tanabe, M ^{[1
]}

Nomoto, M ^{[1
]}

Kohno, K ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Dept Mol Biol, Yahatanishi Ku, Fukuoka 8078555, Japan

来源：

ANTI-CANCER DRUGS | 2002年 / 13卷 / 03期

关键词：

cancer; chemosensitivity; pH regulation; vacuolar H+-ATPase;

D O I：

10.1097/00001813-200203000-00005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor cells in vivo often exist In a hypoxic microonvironment with a lower extracellular pH than that surrounding normal cells. Ability to upregulate proton extrusion may be important for tumor cell survival. Such microenvironmental factors may be Involved in the development of resistant subpopulations of tumor cells. In solid tumors, both intracellular and extracellular pH differ between drug-sensitive and -resistant cells, and pH appears critical to the therapeutic effectiveness of anticancer agents. Four major types of pH regulators have been identified In tumor cells: the sodium-proton antiporter, the bicarbonate transporter, the proton-lactate symporter and proton pumps. Understanding mechanisms regulating tumor acidity opens up novel opportunities for cancer chemotherapy. In this minireview, we describe the structure and function of certain proton pumps overexpressed in many tumors-vacuolar H+-ATPases-and consider their potential as targets for cancer chemotherapy. [ (C) 2002 Lippincott Williams Wilkins.].

引用

页码：237 / 243

页数：7