Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis

被引：265

作者：

Yuan, Joan ^{[1
]}

Nguyen, Cuong K. ^{[1
]}

Liu, Xiuhuai ^{[1
]}

Kanellopoulou, Chrysi ^{[1
]}

Muljo, Stefan A. ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE | 2012年 / 335卷 / 6073期

关键词：

CD8(+) T-CELLS; STEM-CELLS; DEVELOPMENTAL SWITCH; MICRORNA BIOGENESIS; B-LYMPHOPOIESIS; NKT CELLS; EXPRESSION; LEVEL; MOUSE; MICE;

D O I：

10.1126/science.1216557

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The immune system develops in waves during ontogeny; it is initially populated by cells generated from fetal hematopoietic stem cells (HSCs) and later by cells derived from adult HSCs. Remarkably, the genetic programs that control these two distinct stem cell fates remain poorly understood. We report that Lin28b is specifically expressed in mouse and human fetal liver and thymus, but not in adult bone marrow or thymus. We demonstrate that ectopic expression of Lin28 reprograms hematopoietic stem/progenitor cells (HSPCs) from adult bone marrow, which endows them with the ability to mediate multilineage reconstitution that resembles fetal lymphopoiesis, including increased development of B-1a, marginal zone B, gamma/delta (gamma delta) T cells, and natural killer T (NKT) cells.

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页码：1195 / 1200

页数：6

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