Myeloproliferative Neoplasm Animal Models

被引：28

作者：

Mullally, Ann ^{[1
]}

Lane, Steven W. ^{[2
]}

Brumme, Kristina ^{[1
]}

Ebert, Benjamin L. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Div Hematol, Sch Med,Dept Med, Boston, MA 02115 USA

[2] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2012年 / 26卷 / 05期

关键词：

Myeloproliferative neoplasms; Preclinical murine models; BCR-ABL; JAK2V617F; Hematopoietic stem cells; Bone marrow microenvironment; Myelofibrosis; Oncogenes; CHRONIC MYELOGENOUS LEUKEMIA; HEMATOPOIETIC STEM-CELLS; CHRONIC MYELOMONOCYTIC LEUKEMIA; MURINE MODEL; POLYCYTHEMIA-VERA; BONE-MARROW; MYELOID-LEUKEMIA; JAK2; INHIBITOR; CHRONIC-PHASE; MOUSE MODEL;

D O I：

10.1016/j.hoc.2012.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myeloproliferative neoplasm (MPN) animal models accurately re-capitulate human disease in mice and have been an important tool for the study of MPN biology and therapy. Transplantation of BCR-ABL transduced bone marrow into irradiated syngeneic mice established the field of MPN animal modeling. Genetically engineered MPN animal models have enabled detailed characterization of the effects of specific MPN-associated genetic abnormalities on hematopoietic stem and progenitor cells (HSPCs). Xenograft models have allowed the study of primary human MPN-propagating cells in vivo. JAK2V617F, the most common molecular abnormality in BCR-ABL negative MPN, has been extensively studied using retroviral, transgenic, knock-in and xenograft models.

引用

页码：1065 / +

页数：19

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