A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF

被引：270

作者：

Tao, X

West, AE

Chen, WG

Corfas, G

Greenberg, ME

机构：

[1] Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Program Biol & Biomed Sci, Boston, MA 02115 USA

来源：

NEURON | 2002年 / 33卷 / 03期

关键词：

D O I：

10.1016/S0896-6273(01)00561-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-de pendent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.

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收藏

页码：383 / 395

页数：13

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