GTS-21, a nicotinic agonist, protects against neocortical neuronal cell loss induced by the nucleus basalis magnocellularis lesion in rats

被引：29

作者：

Nanri, M ^{[1
]}

Kasahara, N ^{[1
]}

Yamamoto, J ^{[1
]}

Miyake, H ^{[1
]}

Watanabe, H ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, RES INST WAKAN YAKU ORIENTAL MED, DEPT PHARMACOL, TOYAMA 93001, JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 74卷 / 03期

关键词：

GTS-21; nicotinic agonist; neuronal cell loss;

D O I：

10.1254/jjp.74.285

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effect of subchronically administered GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a selective nicotinic agonist, on neuronal cell loss caused by nucleus basalis magnocellularis (nBM) lesion was studied in rats. After 2 weeks of bilateral nBM excitotoxic lesion, GTS-21 was orally administered once daily for 20 weeks. Neuronal cell loss was observed in layers II-III of the parietal cortex in the lesioned control rats. GTS-21 significantly attenuated the neuron loss in these layers. These results suggest that GTS-21 exhibits a protective action against the neuronal cell death in the parietal cortex and may have a beneficial effect on neurodegenerative disorders such as an Alzheimer-type disease.

引用

页码：285 / 289

页数：5

共 15 条

[1] LONG-TERM NEUROPATHOLOGICAL AND NEUROCHEMICAL EFFECTS OF NUCLEUS BASALIS LESIONS IN THE RAT [J].