5-HT1B receptors, ventral orbitofrontal cortex, and aggressive behavior in mice

被引:52
作者
De Almeida, RM
Rosa, MM
Santos, DM
Saft, DM
Benini, Q
Miczek, KA
机构
[1] Tufts Univ, Dept Psychol, Medford, MA 02155 USA
[2] Univ Vale Rio dos Sinos, Lab Neurociencias, Sao Leopoldo, RS, Brazil
[3] Tufts Univ, Dept Psychiat, Medford, MA 02155 USA
[4] Tufts Univ, Dept Pharmacol, Medford, MA 02155 USA
[5] Tufts Univ, Dept Neurosci, Medford, MA 02155 USA
关键词
5-HT receptors; aggressive behavior; male; microinjection; CP-94,253; GR-127,935; infralimbic cortex; prefrontal cortex;
D O I
10.1007/s00213-006-0333-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale: Systemic injections of 5-HT1B receptor agonists have been shown to have specific anti-aggressive effects in aggressive individuals. One site of action for these drugs is the 5-HT1B receptors in the ventral orbitofrontal cortex (VO PFC), an area that has been implicated in the inhibitory control of behavior and is a terminal region for 5-HT projections. Objective: To assess the anti-aggressive effects of the 5-HT1B receptor agonist CP-94,253 when microinjected into the VO PFC (0.1, 0.56, and 1.0 mu g/0.2 mu l) or into the infralimbic prefrontal cortex (IL PFC; 1.0 mu g/0.2 mu l) in separate groups of aggressive resident male mice. To confirm the 5-HT1B receptor as the critical site of action for the anti-aggressive effects, the 5-HT1B/D antagonist GR-127,935 was microinjected at 10.0 mu g/0.2 mu l into the VO PFC. After recovery from surgery, the anti-aggressive effects of microinjected CP-94,253 were studied during 5-min resident-intruder confrontations that were recorded and analyzed. Results: Microinjections of CP-94,253 (0.56 and 1.0 mu g/0.2 mu l) dose-dependently reduced the frequency of attack bites and sideways threats. This effect was behaviorally specific because non-aggressive motor activities were not significantly altered by the drug. In the IL vmPFC or in an area lateral to the VO PFC, CP-94,253 (1.0 mu g/0.2 mu l) did not have significant behavioral effects. Conclusions: The results highlight the 5-HT1B receptors in the VO PFC as a particularly important site for the inhibition of species-typical aggressive behavior in male mice.
引用
收藏
页码:441 / 450
页数:10
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