Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein

被引：97

作者：

Hooijberg, JH ^{[1
]}

Broxterman, HJ ^{[1
]}

Heijn, M ^{[1
]}

Fles, DLA ^{[1
]}

Lankelma, J ^{[1
]}

Pinedo, HM ^{[1
]}

机构：

[1] VRIJE UNIV AMSTERDAM,ACAD ZIEKENHUIS,DEPT MED ONCOL,NL-1007 MB AMSTERDAM,NETHERLANDS

来源：

FEBS LETTERS | 1997年 / 413卷 / 02期

关键词：

multidrug resistance; multidrug resistance protein; (iso)flavonoids; flavopiridol; dinitrophenyl-S-glutathione; ATPase;

D O I：

10.1016/S0014-5793(97)00940-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The multidrug resistance protein (MRP) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we report that dinitrophenyl-S-glutathione increases ATPase activity in plasma membrane vesicles prepared from the MRP-overexpressing cell line GLC4/ADR. This ATPase stimulation parallels the uptake of DNP-SG in these vesicles, We also show that the (iso)flavonoids genistein, kaempferol and flavopiridol stimulate the ATPase activity of GLC4/ADR membranes, whereas genistin has no effect. The present data are consistent with the hypothesis that certain (iso)flavonoids affect MRP-mediated transport of anticancer drugs by a direct interaction with MRP. (C) 1997 Federation of European Biochemical Societies.

引用

页码：344 / 348

页数：5

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