Impact of immobilized polysaccharide chiral stationary phases on enantiomeric separations

被引：110

作者：

Ali, I

Aboul-Enein, HY

机构：

[1] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Cairo 12311, Egypt

[2] Natl Inst Hydrol, Roorkee, Uttar Pradesh, India

来源：

JOURNAL OF SEPARATION SCIENCE | 2006年 / 29卷 / 06期

关键词：

chiral separations; chiralpak IA; chiralpak IB; immobilization; polysaccharide CSP;

D O I：

10.1002/jssc.200500372

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Immobilized polysaccharide-based chiral stationary phases (CSPs) are gaining importance in the resolution of racemic compounds due to their stable nature on working with normal solvents and those prohibited for use with coated phases (tetrahydrofuran, chloroform, dichloromethane, acetone, 1,4-dioxane, ethyl acetate, and certain other ethers). This review discusses the use of immobilized polysaccharide CSPs in the chiral resolution of various racemates by liquid chromatography. The discussion includes immobilization methodologies, enantioselectivities, efficiencies, and a comparison of chiral recognition capabilities of coated vs. immobilized CSPs. Some applications of immobilized CSPs to the chiral resolution of racemic compounds are also presented.

引用

收藏

页码：762 / 769

页数：8

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