Covalently bonded polysaccharide derivatives as chiral stationary phases in high-performance liquid chromatography

被引：188

作者：

Franco, P

Senso, A

Oliveros, L

Minguillón, C

机构：

[1] Univ Barcelona, Fac Farm, Quim Farmaceut Lab, E-08028 Barcelona, Spain

[2] Conservatoire Natl Arts & Metiers, Lab Chim Gen, F-75141 Paris 03, France

来源：

JOURNAL OF CHROMATOGRAPHY A | 2001年 / 906卷 / 1-2期

关键词：

reviews; chiral stationary phases; LC; enantiomer separations; polysaccharide derivatives; cellulose; amylose; chitosan;

D O I：

10.1016/S0021-9673(00)00531-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Polysaccharide derivatives have been extensively used as chromatographic chiral selectors in chiral stationary phases (CSPs) for the separation of enantiomers by HPLC. When coated onto a silica matrix, they represent nowadays one of the most popular type of CSPs. However, they are only compatible with a limited choice of solvents. The main drawback of these CSPs is related to the solubility of the chiral selector in a number of solvents, which Limits their applicability. The different attempts which have been described up to now to overcome this problem by covalently fixing the chiral selector to a matrix are reviewed in this paper. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：155 / 170

页数：16

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