Solvent versatility of bonded cellulose-derived chiral stationary phases for high-performance liquid chromatography and its consequences in column loadability

被引：44

作者：

Franco, P

Minguillón, C

Oliveros, L

机构：

[1] Univ Barcelona, Fac Farm, Quim Farmaceut Lab, E-08028 Barcelona, Spain

[2] Conservatoire Natl Arts & Metiers, Lab Chim Gen, F-75141 Paris 03, France

来源：

JOURNAL OF CHROMATOGRAPHY A | 1998年 / 793卷 / 02期

关键词：

chiral stationary phases; LC; mobile phase composition; benzodiazepines; warfarin; beta-blockers; naproxen;

D O I：

10.1016/S0021-9673(97)00935-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The chromatographic behaviour of a 10-undecenoate/3,5-dimethylphenylcarbamate of cellulose bonded on allylsilica gel is tested using four organic mobile-phase modifiers (2-propanol, chloroform, tetrahydrofuran and ethyl acetate). The advantages of the broad choice of solvents offered by this kind of chiral stationary phases and their resistance are discussed. The loadability of the column and its dependence both on the racemate to be resolved and on the solvent used as mobile phase are also discussed. (C) 1998 Elsevier Science B.V.

引用

页码：239 / 247

页数：9

共 18 条

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Dingenen J., 1994, PRACTICAL APPROACH C

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