In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes

被引：111

作者：

Guo, Yan ^{[1
]}

Shi, Donglu ^{[1
,2
,3
]}

Cho, Hoonsung ^{[1
]}

Dong, Zhongyun ^{[4
]}

Kulkarni, Amit ^{[5
]}

Pauletti, Giovanni M. ^{[5
]}

Wang, Wei ^{[1
]}

Lian, Jie ^{[6
]}

Liu, Wen ^{[10
]}

Ren, Lei ^{[10
]}

Zhang, Qiqing ^{[10
]}

Liu, Guokui ^{[11
]}

Huth, Christopher ^{[1
]}

Wang, Lumin ^{[7
,8
,9
]}

Ewing, Rodney C. ^{[7
,8
,9
]}

机构：

[1] Univ Cincinnati, Dept Chem & Mat Engn, Cincinnati, OH 45221 USA

[2] Shanghai Jiao Tong Univ, Res Inst Micro Nano Sci & Technol, Shanghai 200092, Peoples R China

[3] Tongji Univ, Coll Mat Sci & Engn, Shanghai 200092, Peoples R China

[4] Univ Cincinnati, Coll Med, Dept Internal Med, Cincinnati, OH 45267 USA

[5] Univ Cincinnati, James L Winkle Coll Pharm, Cincinnati, OH 45221 USA

[6] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA

[7] Univ Michigan, Dept Geol Sci, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Dept Nucl Engn & Radiol Sci, Ann Arbor, MI 48109 USA

[9] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

[10] Xiamen Univ, Biomed Engn Res Ctr, Coll Med, Xiamen 361005, Fujian, Peoples R China

[11] Argonne Natl Lab, Div Chem, Argonne, IL 60439 USA

来源：

ADVANCED FUNCTIONAL MATERIALS | 2008年 / 18卷 / 17期

关键词：

D O I：

10.1002/adfm.200800406

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A specially designed carbon nanotube (CNT) is developed for use in the early detection and treatment of cancer. The key functionalities for biomedical diagnosis and drug delivery are incorporated into the CNTs. In vivo imaging of live mice is achieved by intravenously injecting quantum dot (QD)-conjugated CNT for the first time. With near infrared emission around 752 nm, the CNT with surface-conjugated QD (CNT-QD) exhibit a strong luminescence for non-invasive optical in vivo imaging. CNT surface modification is achieved by a plasma polymerization approach that deposited ultra-thin acrylic acid or poly(lactic-co-glycolic acid) (PLGA) films (similar to 3 nm) onto the nanotubes. The anticancer agent paclitaxel is loaded at 11.2 +/- 5.8 mu g mg(-1) to PLGA-coated CNT. Cytotoxicity of this novel drug delivery system is evaluated in vitro using PC-3MM2 human prostate carcinoma cells and quantified by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The in vivo distribution determined by inductively coupled plasma mass spectrometry (ICP-MS) indicates CNT-QD uptake in various organs of live animals.

引用

页码：2489 / 2497

页数：9

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