T-helper-1 and t-helper-2 responses in psychiatric disorders

被引:167
作者
Schwarz, MJ [1 ]
Chiang, SN [1 ]
Müller, N [1 ]
Ackenheil, M [1 ]
机构
[1] Univ Munich, Hosp Psychiat, D-80336 Munich, Germany
关键词
schizophrenia; major depression; Alzheimer's disease; Th1; Th2; adaptive immune system; immunopsychiatry; psychoneuroimmunology;
D O I
10.1006/brbi.2001.0647
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The expanding field of psychoneuroimmunology has markedly increased knowledge about the interference of the central nervous system and the immune system. Immunological abnormalities in psychiatric patients have been repeatedly described in the last century. Modem concepts of immunology and the growing knowledge of psychoneuroimmunology may help in understanding the distinct immunological mechanisms in psychiatric disorders. One of these concepts regarding the adaptive immune system is the discrimination between Th1-like cell-mediated and Th2-like anti body-related immune responses. This article systematically describes alterations of Th1- or Th2-specific parameters in the major psychiatric disorders schizophrenia, major depression, and Alzheimer's disease. There are several hints of associations of these two distinct arms of immune response with subgroups of schizophrenia and major depression. The immunological research in Alzheimer's disease has already led to a preclinical model of immumotherapy. Categorization of immune parameters may also help to identify a possible immune-related pathophysiology in psychotic and affective disorders, resulting in specific treatment strategies. (C) 2001 Elsevier Science.
引用
收藏
页码:340 / 370
页数:31
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