Anabaenopeptins G and H, potent carboxypeptidase A inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-595)

被引：82

作者：

Itou, Y ^{[1
]}

Suzuki, S ^{[1
]}

Ishida, K ^{[1
]}

Murakami, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Marine Biochem Lab, Bunkyo Ku, Tokyo 1138657, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(99)00191-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Anabaenopeptins G (1) and H (2) were isolated from the cultured cyanobacterium Oscillatoria agardhii (NIES-595) as potent carboxypeptidase A (CPA) inhibitors. The gross structure of 1 and 2 were established by spectroscopic analysis including the 2D NMR technique and the absolute configurations of 1 and 2 were determined by the spectral and chemical methods. 1 and 2 inhibited CPA with IC50's of 0.0018 and 3.4 mu g/mL, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1243 / 1246

页数：4

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