Radiosumin, a trypsin inhibitor from the blue-green Alga Plectonema radiosum

被引：23

作者：

Matsuda, H ^{[1
]}

Okino, T ^{[1
]}

Murakami, M ^{[1
]}

Yamaguchi, K ^{[1
]}

机构：

[1] UNIV TOKYO, GRAD SCH AGR LIFE SCI, MARINE BIOCHEM LAB, BUNKYO KU, TOKYO 113, JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 24期

关键词：

D O I：

10.1021/jo961130m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radiosumin, a novel potent trypsin inhibitory dipeptide, was isolated from the freshwater blue-green alga Plectonema radiosum (NIES-515). Its structure was elucidated to be 1 on the basis of 2D NMR data and chemical degradation. The IC50 of 1 against trypsin was 0.14 mu g/mL.

引用

页码：8648 / 8650

页数：3

共 12 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].

BAX, A ;

SUMMERS, MF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094

[2] SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY [J].

BAX, A ;

SUBRAMANIAN, S .

JOURNAL OF MAGNETIC RESONANCE, 1986, 67 (03) :565-569

[3] RESULTS OF A LARGE-SCALE SCREEN OF MICROALGAE FOR THE PRODUCTION OF PROTEASE INHIBITORS [J].

CANNELL, RJP ;

KELLAM, SJ ;

OWSIANKA, AM ;

WALKER, JM .

PLANTA MEDICA, 1988, (01) :10-14

[4] TOTAL STRUCTURE OF HORMOTHAMNIN-A, A TOXIC CYCLIC UNDECAPEPTIDE FROM THE TROPICAL MARINE CYANOBACTERIUM HORMOTHAMNION-ENTEROMORPHOIDES [J].

GERWICK, WH ;

JIANG, ZD ;

AGARWAL, SK ;

FARMER, BT .

TETRAHEDRON, 1992, 48 (12) :2313-2324

[5] MICROVIRIDIN - A NOVEL TRICYCLIC DEPSIPEPTIDE FROM THE TOXIC CYANOBACTERIUM MICROCYSTIS-VIRIDIS [J].

ISHITSUKA, MO ;

KUSUMI, T ;

KAKISAWA, H ;

KAYA, K ;

WATANABE, MM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (22) :8180-8182

[6] CALOPHYCIN, A FUNGICIDAL CYCLIC DECAPEPTIDE FROM THE TERRESTRIAL BLUE-GREEN-ALGA CALOTHRIX-FUSCA [J].

MOON, SS ;

CHEN, JL ;

MOORE, RE ;

PATTERSON, GML .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (04) :1097-1103

[7] AERUGINOSIN 298-A, A THROMBIN AND TRYPSIN-INHIBITOR FROM THE BLUE-GREEN-ALGA MICROCYSTIS-AERUGINOSA (NIES-298) [J].

MURAKAMI, M ;

OKITA, Y ;

MATSUDA, H ;

OKINO, T ;

YAMAGUCHI, K .

TETRAHEDRON LETTERS, 1994, 35 (19) :3129-3132

[8] AERUGINOSIN-98-A AND AERUGINOSIN-98-B, TRYPSIN-INHIBITORS FROM THE BLUE-GREEN-ALGA MICROCYSTIS-AERUGINOSA (NIES-98) [J].

MURAKAMI, M ;

ISHIDA, K ;

OKINO, T ;

OKITA, Y ;

MATSUDA, H ;

YAMAGUCHI, K .

TETRAHEDRON LETTERS, 1995, 36 (16) :2785-2788

[9] MICROGININ, AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR FROM THE BLUE-GREEN-ALGA MICROCYSTIS-AERUGINOSA [J].

OKINO, T ;

MATSUDA, H ;

MURAKAMI, M ;

YAMAGUCHI, K .

TETRAHEDRON LETTERS, 1993, 34 (03) :501-504

[10] MICROPEPTIN-A AND MICROPEPTIN-B, PLASMIN AND TRYPSIN-INHIBITORS FROM THE BLUE-GREEN-ALGA MICROCYSTIS-AERUGINOSA [J].

OKINO, T ;

MURAKAMI, M ;

HARAGUCHI, R ;

MUNEKATA, H ;

MATSUDA, H ;

YAMAGUCHI, K .

TETRAHEDRON LETTERS, 1993, 34 (50) :8131-8134

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