Efficient route to 2H-1,3-oxazines through ring expansion of isoxazoles by rhodium carbenoids

被引：68

作者：

Manning, James R. ^{[1
]}

Davies, Huw M. L. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

TETRAHEDRON | 2008年 / 64卷 / 29期

关键词：

isoxazole ring expansion; N-O insertion; rhodium carbenoid; aryldiazoacetates;

D O I：

10.1016/j.tet.2008.03.010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Studies related to the total synthesis of elisabethin C led to the discovery of a rhodiurn-catalyzed cascade sequence involving isoxazole ring expansion and a [4+3] cycloaddition. The scope of the isoxazole ring expansion was explored, resulting in the synthesis of a range of 2H-1,3-oxazines in 47-96% yield. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6901 / 6908

页数：8

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