Cytotoxic activity and QSAR of N,N′-diarylalkanediamides

被引：5

作者：

Chacón-García, L ^{[1
]}

Martínez, R ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 36卷 / 09期

关键词：

cytotoxic activity; QSAR; N; '-diarylalkanediamides;

D O I：

10.1016/S0223-5234(01)01260-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The one- and two-step syntheses of N,N'-(dinitrophenyl)alkanediamides and N,N'-(diaminophenyl)alkanediamides from 4-nitroaniline were carried out. These compounds were subjected to cytotoxic evaluation against different tumoural cell lines. A QSAR analysis for the aminated series, introducing a QSAR descriptor (DCL) designed herein for groove binders, reveals that the activity in the K562 cell line is related to the charge, polarisability, volume and length of the molecules. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：731 / 736

页数：6

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