Synthesis and cytotoxic evaluation of N1,Nm-bis[(tetrahydrobenzo[a]acridin-12-yl)phenyl]alkanediamides and N1,Nm-bis[(tetrahydrobenzo[c]acridin-7-yl)phenyl]-alkanediamides

被引：10

作者：

Martínez, R

Cogordan, JA

Mancera, C

Díaz, ML

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[2] UAEM, Fac Ciencias Quim Ind, DES, Dept Quim Organ, Cuernavaca, Morelos, Mexico

来源：

FARMACO | 2000年 / 55卷 / 9-10期

关键词：

synthesis; benzacridines; alkanediamides; anticancer activity;

D O I：

10.1016/S0014-827X(00)00073-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The title compounds were synthesized in four steps from 5,5-dimethyl-1, 3-cyclohexanedione as starting material. These compounds were evaluated against 60 tumoral cell lines, whereas the N-I,N-m-bis[benzo[c]acridin-7-yl]phenyl] alkanediamides displaying significant cytotoxic activity, the corresponding N-I,N-m-bis[benzo[a]acridin-12-yl]phenyl]alkanediamides derivatives were found to be less cytotoxic. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

收藏

页码：631 / 636

页数：6

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