Pathogenic features of CD4+CD28- T cells in immune disorders

被引：97

作者：

Broux, Bieke ^{[1
,2
]}

Markovic-Plese, Silva ^{[3
,4
]}

Stinissen, Piet ^{[1
,2
]}

Hellings, Niels ^{[1
,2
]}

机构：

[1] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium

[2] Transnat Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium

[3] Univ N Carolina, Dept Neurol, Chapel Hill, NC 27514 USA

[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27514 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 08期

关键词：

ACUTE CORONARY SYNDROMES; RHEUMATOID-ARTHRITIS PATIENTS; MULTIPLE-SCLEROSIS PATIENTS; CD28; EXPRESSION; UNSTABLE ANGINA; CARDIOVASCULAR-DISEASE; AUTOIMMUNE-DISEASE; INTERFERON-GAMMA; ARTERY-DISEASE; NERVOUS-SYSTEM;

D O I：

10.1016/j.molmed.2012.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging of the immune system contributes to the increased morbidity and mortality of the elderly population and may occur prematurely in patients with immune disorders. One of the main characteristics of immunosenescence is the expansion of CD4(+)CD28(-) T cells in the blood. These cells are effector memory T cells with cytotoxic capacity, and have been recently described to have pathogenic potential in a variety of immune disorders. Interestingly, CD4(+)CD28(-) T cells have now been found to infiltrate target tissues of patients with multiple sclerosis, rheumatoid arthritis, myopathies, acute coronary syndromes, and other immune-related diseases. In this review, we discuss potential factors and mechanisms that may induce the expansion of these cells, as well as their putative pathogenic mechanisms in immune disorders.

引用

页码：446 / 453

页数：8