Spectral Tuning of Azobenzene Photoswitches for Biological Applications

被引：191

作者：

Sadovski, Oleg ^{[1
]}

Beharry, Andrew A. ^{[1
]}

Zhang, Fuzhong ^{[1
]}

Woolley, G. Andrew ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

azo compounds; isomerization; peptides; photoswitches; TO-TRANS ISOMERIZATION; AZO DYES; ABSORPTION-SPECTRA; ION CHANNELS; AMINO-ACID; PEPTIDE;

D O I：

10.1002/anie.200805013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Longer switching wavelengths and good photochemical yields and stabilities of the cis isomers in reducing aqueous environments are achieved by introducing 2,2 -aminoalkyl substituents into 4,4 - diamido-substituted azobenzenes. The products are thus suitable for photocontrol of biomolecular structures in intracellular environments, such as switching between two peptide configurations (see pictures). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1484 / 1486

页数：3

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