Recent progress in West Nile virus diagnosis and vaccination

被引:111
作者
De Filette, Marina [1 ]
Ulbert, Sebastian [2 ]
Diamond, Mike [3 ,4 ,5 ]
Sanders, Niek N. [1 ]
机构
[1] Univ Ghent, Fac Vet Sci, Lab Gene Therapy, B-9820 Merelbeke, Belgium
[2] Fraunhofer Inst Cell Therapy & Immunol, Vaccine Technol Unit, D-04103 Leipzig, Germany
[3] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
关键词
MEDIATED ISOTHERMAL AMPLIFICATION; LINKED IMMUNOSORBENT ASSAYS; NONSTRUCTURAL PROTEIN NS1; CYCLE FLAVIVIRUS VACCINE; CENTRAL-NERVOUS-SYSTEM; CD8(+) T-CELLS; RAPID DETECTION; REPLIVAX WN; DNA VACCINE; DOMAIN-III;
D O I
10.1186/1297-9716-43-16
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
West Nile virus (WNV) is a positive-stranded RNA virus belonging to the Flaviviridae family, a large family with 3 main genera (flavivirus, hepacivirus and pestivirus). Among these viruses, there are several globally relevant human pathogens including the mosquito-borne dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV) and West Nile virus (WNV), as well as tick-borne viruses such as tick-borne encephalitis virus (TBEV). Since the mid-1990s, outbreaks of WN fever and encephalitis have occurred throughout the world and WNV is now endemic in Africa, Asia, Australia, the Middle East, Europe and the Unites States. This review describes the molecular virology, epidemiology, pathogenesis, and highlights recent progress regarding diagnosis and vaccination against WNV infections.
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页数:15
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