The role of targeted therapy in ovarian cancer

被引：47

作者：

Banerjee, Susana ^{[1
]}

Kaye, Stan ^{[1
]}

机构：

[1] Royal Marsden NHS Fdn Trust, Sutton, Surrey, England

来源：

EUROPEAN JOURNAL OF CANCER | 2011年 / 47卷

关键词：

RECURRENT EPITHELIAL OVARIAN; PHASE-II TRIAL; PRIMARY PERITONEAL CARCINOMA; RIBOSE POLYMERASE INHIBITORS; FALLOPIAN-TUBE CANCER; PLATINUM-RESISTANT; GROWTH-FACTOR; POLY(ADP-RIBOSE) POLYMERASE; IMATINIB MESYLATE; TUMOR VASCULATURE;

D O I：

10.1016/S0959-8049(11)70155-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ovarian cancer is the second most common gynaecological malignancy and the leading cause of death from gynaecological cancer. Although in some cases treatment is initially effective, there is a considerable risk of disease recurrence and resistance to therapy. Therapies targeting molecular alterations in tumours offer the promise of significantly improved treatment. So far, the most promising targeted agents are angiogenesis inhibitors and PARP inhibitors. Here, we review the various targeted therapeutic approaches under clinical investigation in phase I and II trials of ovarian cancer and the challenges facing their future success in the clinic.

引用

页码：S116 / S130

页数：15

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