Carbohydrate peptide mimics: effect on MUC1 cancer immunotherapy

被引：35

作者：

Apostolopoulos, V ^{[1
]}

Sandrin, MS ^{[1
]}

McKenzie, IFC ^{[1
]}

机构：

[1] Austin Res Inst, Heidelberg, Vic 3084, Australia

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1999年 / 77卷 / 05期

关键词：

immune deviation; mimics; galactose alpha(1,3)galactose; MUC1; immunotherapy;

D O I：

10.1007/s001090050373

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent clinical studies with mannan mucin immunotherapeutic agents indicate that patients produce predominantly antibody responses while mice produce a high cytotoxic T lymphocyte response. In studying the reason for the 'immune deviation' occurring in mice to humans from cellular to antibody responses, it has been found that natural anti-Gal alpha(1,3)Gal antibodies, present in all humans, react with the mucin component of the agent, providing an example of a carbohydrate-peptide mimic. The immune deviation can be overcome by in vitro sensitization of antigen-presenting cells in the absence of anti-Gal antibodies - at least in mice. The review examines the background of these observations and discusses other peptide carbohydrate mimics and immune deviation.

引用

页码：427 / 436

页数：10

共 58 条

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