Carbohydrate peptide mimics: effect on MUC1 cancer immunotherapy

被引：35

作者：

Apostolopoulos, V ^{[1
]}

Sandrin, MS ^{[1
]}

McKenzie, IFC ^{[1
]}

机构：

[1] Austin Res Inst, Heidelberg, Vic 3084, Australia

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1999年 / 77卷 / 05期

关键词：

immune deviation; mimics; galactose alpha(1,3)galactose; MUC1; immunotherapy;

D O I：

10.1007/s001090050373

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent clinical studies with mannan mucin immunotherapeutic agents indicate that patients produce predominantly antibody responses while mice produce a high cytotoxic T lymphocyte response. In studying the reason for the 'immune deviation' occurring in mice to humans from cellular to antibody responses, it has been found that natural anti-Gal alpha(1,3)Gal antibodies, present in all humans, react with the mucin component of the agent, providing an example of a carbohydrate-peptide mimic. The immune deviation can be overcome by in vitro sensitization of antigen-presenting cells in the absence of anti-Gal antibodies - at least in mice. The review examines the background of these observations and discusses other peptide carbohydrate mimics and immune deviation.

引用

收藏

页码：427 / 436

页数：10

相关论文

共 58 条

[11] Molecular analysis of the modulatory factors of the response to HBsAg in mice as an approach to HBV vaccine enhancement [J].

Bouige, P ;

Iscaki, S ;

Cosson, A ;

Pillot, J .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1996, 13 (01) :71-79

[12] MODULATION OF THE IMMUNOLOGICAL RESPONSE TO HEPATITIS-B VIRUS BY ANTIBODIES [J].

CELIS, E ;

ABRAHAM, KG ;

MILLER, RW .

HEPATOLOGY, 1987, 7 (03) :563-568

[13] ROLE OF CYTOKINES IN THE DIFFERENTIATION OF CD4+ T-CELL SUBSETS INVIVO [J].

COFFMAN, RL ;

VARKILA, K ;

SCOTT, P ;

CHATELAIN, R .

IMMUNOLOGICAL REVIEWS, 1991, 123 :189-207

[14] Molecular mimicry: Can epitope mimicry induce autoimmune disease? [J].

Davies, JM .

IMMUNOLOGY AND CELL BIOLOGY, 1997, 75 (02) :113-126

[15] Autoimmune diabetes:: The role of T cells, MHC molecules and autoantigens [J].

Durinovic-Belló, I .

AUTOIMMUNITY, 1998, 27 (03) :159-177

[16] Enhancement of antigen presentation of influenza virus hemagglutinin by the natural human anti-Gal antibody [J].

Galili, U ;

Repik, PM ;

Anaraki, F ;

Mozdzanowska, K ;

Washko, G ;

Gerhard, W .

VACCINE, 1996, 14 (04) :321-328

[17]

GALILI U, 1988, J BIOL CHEM, V263, P17755

[18] Natural anti-Gal antibody as a universal augmenter of autologous tumor vaccine immunogenicity [J].

Galili, U ;

LaTemple, DC .

IMMUNOLOGY TODAY, 1997, 18 (06) :281-285

[19] Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells [J].

Gong, J ;

Chen, L ;

Chen, D ;

Kashiwaba, M ;

Manome, Y ;

Tanaka, T ;

Kufe, D .

GENE THERAPY, 1997, 4 (10) :1023-1028

[20] Exploring the basis of peptide-carbohydrate crossreactivity: Evidence for discrimination by peptides between closely related anti-carbohydrate antibodies [J].

Harris, SL ;

Craig, L ;

Mehroke, JS ;

Rashed, M ;

Zwick, MB ;

Kenar, K ;

Toone, EJ ;

Greenspan, N ;

Auzanneau, FI ;

MarinoAlbernas, JR ;

Pinto, BM ;

Scott, JK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2454-2459

← 1 2 3 4 5 6 →