Natural anti-Gal antibody as a universal augmenter of autologous tumor vaccine immunogenicity

被引：78

作者：

Galili, U

LaTemple, DC

机构：

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(97)80024-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunogenicity of tumor-associated antigens (TAAs) in autologous tumor vaccines is usually very low. Here, the possibility is discussed that TAA immunogenicity might be increased in any human tumor-cell vaccine by engineering the vaccinating membranes to express alpha-galactosyl epitopes. Binding of host anti-Gal antibodies to these epitopes would augment the uptake and presentation of TAAs on vaccinating membranes by antigen-presenting cells.

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页码：281 / 285

页数：5

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