Natural anti-Gal antibody as a universal augmenter of autologous tumor vaccine immunogenicity

被引：78

作者：

Galili, U

LaTemple, DC

机构：

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(97)80024-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunogenicity of tumor-associated antigens (TAAs) in autologous tumor vaccines is usually very low. Here, the possibility is discussed that TAA immunogenicity might be increased in any human tumor-cell vaccine by engineering the vaccinating membranes to express alpha-galactosyl epitopes. Binding of host anti-Gal antibodies to these epitopes would augment the uptake and presentation of TAAs on vaccinating membranes by antigen-presenting cells.

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页码：281 / 285

页数：5

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共 58 条

[11] THE HUMAN NATURAL ANTI-GAL IGG .3. THE SUBTLETY OF IMMUNE TOLERANCE IN MAN AS DEMONSTRATED BY CROSS-REACTIVITY BETWEEN NATURAL ANTI-GAL AND ANTI-B ANTIBODIES [J].

GALILI, U ;

BUEHLER, J ;

SHOHET, SB ;

MACHER, BA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (03) :693-704

[12]

GALILI U, 1988, J BIOL CHEM, V263, P17755

[13] GENE-SEQUENCES SUGGEST INACTIVATION OF ALPHA-1,3-GALACTOSYLTRANSFERASE IN CATARRHINES AFTER THE DIVERGENCE OF APES FROM MONKEYS [J].

GALILI, U ;

SWANSON, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :7401-7404

[14] A UNIQUE NATURAL HUMAN-IGG ANTIBODY WITH ANTI-ALPHA-GALACTOSYL SPECIFICITY [J].

GALILI, U ;

RACHMILEWITZ, EA ;

PELEG, A ;

FLECHNER, I .

JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (05) :1519-1531

[15] HUMAN NATURAL ANTI-ALPHA-GALACTOSYL IGG .2. THE SPECIFIC RECOGNITION OF ALPHA-(1 -] 3)-LINKED GALACTOSE RESIDUES [J].

GALILI, U ;

MACHER, BA ;

BUEHLER, J ;

SHOHET, SB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (02) :573-582

[16] EVOLUTIONARY RELATIONSHIP BETWEEN THE NATURAL ANTI-GAL ANTIBODY AND THE GAL-ALPHA-1-]3GAL EPITOPE IN PRIMATES [J].

GALILI, U ;

CLARK, MR ;

SHOHET, SB ;

BUEHLER, J ;

MACHER, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) :1369-1373

[17] INTERACTION OF THE NATURAL ANTI-GAL ANTIBODY WITH ALPHA-GALACTOSYL EPITOPES - A MAJOR OBSTACLE FOR XENOTRANSPLANTATION IN HUMANS [J].

GALILI, U .

IMMUNOLOGY TODAY, 1993, 14 (10) :480-482

[18] INTERACTION BETWEEN HUMAN NATURAL ANTI-ALPHA-GALACTOSYL IMMUNOGLOBULIN-G AND BACTERIA OF THE HUMAN FLORA [J].

GALILI, U ;

MANDRELL, RE ;

HAMADEH, RM ;

SHOHET, SB ;

GRIFFISS, JM .

INFECTION AND IMMUNITY, 1988, 56 (07) :1730-1737

[19]

GALILI U, 1993, SPRINGER SEMIN IMMUN, V15, P155

[20] SUPPRESSION OF ALPHA-GALACTOSYL EPITOPES SYNTHESIS AND PRODUCTION OF THE NATURAL ANTI-GAL ANTIBODY - A MAJOR EVOLUTIONARY EVENT IN ANCESTRAL OLD-WORLD PRIMATES [J].

GALILI, U ;

ANDREWS, P .

JOURNAL OF HUMAN EVOLUTION, 1995, 29 (05) :433-442

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