Cardiovascular effects of neuropeptide FF antagonists

被引：16

作者：

Prokai, Laszlo

Zharikova, Aleutina D.

Juhasz, Attila

Prokai-Tatrai, Katalin

机构：

[1] Univ Florida, Coll Pharm, Dept Med Chem, Gainesville, FL 32610 USA

[2] Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA

[3] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA

[4] Univ Debrecen, Sch Med, Dept Med 1, Debrecen, Hungary

来源：

PEPTIDES | 2006年 / 27卷 / 05期

关键词：

neuropeptide FF; antagonist; hemodynamic parameters; rat;

D O I：

10.1016/j.peptides.2005.06.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH2 dose-dependently reversed NPFF-induced elevation of blood pressure in anesthetized rats after intravenous injection without causing a significant change of blood pressure and heart rate by itself. However, another antagonist dansyl-Pro-Gln-Arg-NH2 produced a significant drop of the mean arterial pressure only at a large dose (10 mu mol/kgbody weight), but reversal of the NPFF-induced hypertension was modest. Consequently and contrary to the conclusions of a previous study, NPFF antagonists cannot be identified simply by measuring the changes in the hemodynamic parameters upon the injection of the compounds alone and, without a subsequent NPFF challenge. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1015 / 1019

页数：5

共 21 条

[11] Relevance of the C-terminal Arg-Phe sequence in γ2-melanocyte-stimulating hormone (γ2-MSH) for inducing cardiovascular effects in conscious rats [J].