Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

被引：21

作者：

Kim, YK

Kim, SH

Choi, SH

Ko, YH

Kim, L

Lee, MS

Suh, KY

Kwak, DI

Song, KJ

Lee, YJ

Yanagihara, R

Song, JW

机构：

[1] Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea

[2] Korea Univ, Inst Viral Dis, Seoul 136705, South Korea

[3] Korea Univ, Dept Psychiat, Seoul 136705, South Korea

[4] YongIn Mental Hosp, Yongin Kun 449910, Kyungki Do, South Korea

[5] Univ Hawaii Manoa, Pacific Biomed Res Ctr, Retrovirol Res Lab, Honolulu, HI 96816 USA

来源：

JOURNAL OF NEUROVIROLOGY | 1999年 / 5卷 / 02期

基金：

美国国家科学基金会;

关键词：

Borna disease virus; RT-PCR; PBMC; psychiatric disorders;

D O I：

10.3109/13550289909022002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RNA, extracted from peripheral blood mononuclear cells (PBMSC) obtained ham 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein-encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase chain reaction (RT - PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

引用

页码：196 / 199

页数：4

共 26 条

[21] POLYMERASE CHAIN-REACTION (PCR) SEARCH FOR VIRAL NUCLEIC-ACID SEQUENCES IN SCHIZOPHRENIA [J].