Screening for Y microdeletions in men with testicular cancer and undescended testis

被引：10

作者：

Bor, P

Hindkjær, J

Kolvraa, S

Rossen, P

Maase, H

Jorgensen, TM

Sorensen, VT

Eiberg, H

Ingerslev, HJ

机构：

[1] Fertil Clin, Aarhus, Denmark

[2] Dept Clin Genet, Aarhus, Denmark

[3] Dept Oncol, Aarhus, Denmark

[4] Aarhus Univ Hosp, Dept Urol, DK-8000 Aarhus, Denmark

[5] Randers Cent Hosp, Dept Urol, Aarhus, Denmark

[6] Univ Copenhagen, Panum Inst, DK-2200 Copenhagen, Denmark

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2006年 / 23卷 / 01期

关键词：

capillary electrophoresis; multiplex PCR; oligo-azoospermia; testis cancer; undescended testis; Y microdeletions;

D O I：

10.1007/s10815-005-9001-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. Methods: It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions Results: A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. Conclusions: Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.

引用

页码：41 / 45

页数：5

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