Sin3: Insight into its transcription regulatory functions

被引：122

作者：

Kadamb, Rama ^{[1
]}

Mittal, Shilpi ^{[1
]}

Bansal, Nidhi ^{[1
]}

Batra, Harish ^{[1
]}

Saluja, Daman ^{[1
]}

机构：

[1] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2013年 / 92卷 / 8-9期

关键词：

Sin3A; Sin3B; Histone deacetylase; Co-repressor complex; Transcriptional regulation; Protein stability; HISTONE DEACETYLASE COMPLEX; ESTROGEN-RECEPTOR-ALPHA; RNA-POLYMERASE-II; CELL-CYCLE; DROSOPHILA SIN3; PAH2; DOMAIN; WILD-TYPE; HETEROCHROMATIN FORMATION; COREPRESSOR MSIN3A; REPRESSOR COMPLEX;

D O I：

10.1016/j.ejcb.2013.09.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor complex functions in transcriptional regulation of several genes and is therefore implicated in the regulation of key biological processes. Knockdown studies have confirmed the role of Sin3 in cellular proliferation, differentiation, apoptosis and cell cycle regulation, emphasizing Sin3 as an essential regulator of critical cellular events in normal and pathological processes. The present review covers the diverse functions of this master transcriptional regulator as well as illustrates the redundant and distinct functions of its two mammalian isoforms. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：237 / 246

页数：10

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