Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission

被引：502

作者：

Derdeyn, CA

Decker, JM

Bibollet-Ruche, F

Mokili, JL

Muldoon, M

Denham, SA

Heil, ML

Kasolo, F

Musonda, R

Hahn, BH

Shaw, GM

Korber, BT

Allen, S

Hunter, E ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Howard Hughes Med Inst, Birmingham, AL 35294 USA

[4] Los Alamos Natl Lab, HIV Sequence Database, Los Alamos, NM 87544 USA

[5] Univ Manchester, Inst Sci & Technol, Inst Math, Manchester M60 1QD, Lancs, England

[6] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol & Int Hlth, Birmingham, AL 35294 USA

[7] Univ Alabama Birmingham, Birmingham Ctr AIDS Res, Birmingham, AL 35294 USA

[8] Univ Teaching Hosp, Dept Pathol & Microbiol, Lusaka, Zambia

[9] Trop Dis Res Ctr, Ndola, Zambia

[10] Santa Fe Inst, Santa Fe, NM 87501 USA

来源：

SCIENCE | 2004年 / 303卷 / 5666期

关键词：

D O I：

10.1126/science.1093137

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

引用

页码：2019 / 2022

页数：4

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