Adhesion-mediated signaling in the regulation of mammary epithelial cell survival

被引：80

作者：

Streuli, CH ^{[1
]}

Gilmore, AP ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 1999年 / 4卷 / 02期

关键词：

apoptosis; integrin; basement membrane; insulin; pp125(FAK); phosphatidylinositol 3 '-kinase;

D O I：

10.1023/A:1018729308878

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tissue architecture in multicellular organisms is maintained through adhesive interactions between cells and their neighbors, and between cells and the underlying extracellular matrix. These interactions are important in the dynamic regulation of tissue organization as well as the control of eel! proliferation, differentiation and apoptosis. The ultimate goal of this regulation is to promote cell growth and differentiation only when the cell is in the correct location, and to delete cells that have become displaced from their proper environment. It therefore prays an important role in development and tissue remodeling. In this review we consider the molecular mechanisms by which cell-matrix interactions contribute to cell survival, and discuss their role in mammary gland development and function.

引用

页码：183 / 191

页数：9

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