Remarkable activation of an enzyme by (R)-pyrrolidine-substituted imidazolium alkyl PEG sulfate

被引：32

作者：

Abe, Yoshikazu ^{[1
]}

Hirakawa, Takuya ^{[1
]}

Nakajima, Shino ^{[1
]}

Okano, Nagisa ^{[1
]}

Hayase, Shuichi ^{[1
]}

Kawatsura, Motoi ^{[1
]}

Hirose, Yoshihiko ^{[2
]}

Itoh, Toshiyuki ^{[1
]}

机构：

[1] Tottori Univ, Grad Sch Engn, Dept Chem & Biotechnol, Tottori 6808552, Japan

[2] Amano Enzyme Ltd, Gifu 5090108, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 13期

关键词：

acceleration; enhanced enantioselectivity; enzyme catalysis; lipase; transesterification;

D O I：

10.1002/adsc.200800382

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

The chiral pyrrolidine-substituted imidazolium cetyl-PEG10-sulfate (D-ProMe) derived from D-proline worked as an excellent activating agent of Burkholderia cepacia lipase; it is particularly interesting that the D-isomer of the imidazolium salt worked better than the L-isomer. This suggests that the imidazolium cation group directly interacts with the enzyme protein and causes preferable modification of the reactivity.

引用

页码：1954 / 1958

页数：5

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