Dendrimers as size selective inhibitors to protein-protein binding

被引：32

作者：

Chiba, Fumiko ^{[1
]}

Hu, Ting-Chou ^{[1
]}

Twyman, Lance J. ^{[1
]}

Wagstaff, Mark ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S2 7HF, S Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 36期

关键词：

D O I：

10.1039/b806517a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This communication describes how the "quantized" size effect of dendrimers can be exploited towards a size selective binding mechanism for the inhibition of protein-protein binding.

引用

页码：4351 / 4353

页数：3

共 22 条

[1] Dendrimeric bisphosphonates for multivalent protein surface binding [J].

Arendt, Markus ;

Sun, Wei ;

Thomann, Jens ;

Xie, Xiulan ;

Schrader, Thomas .

CHEMISTRY-AN ASIAN JOURNAL, 2006, 1 (04) :544-554

[2] Pattern-based detection of different proteins using an array of fluorescent protein surface receptors [J].

Baldini, L ;

Wilson, AJ ;

Hong, J ;

Hamilton, AD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (18) :5656-5657

[3] Disruption of protein-protein interactions using nanoparticles: inhibition of cytochrome c peroxidase [J].

Bayraktar, H ;

Ghosh, PS ;

Rotello, VM ;

Knapp, MJ .

CHEMICAL COMMUNICATIONS, 2006, (13) :1390-1392

[4] Anatomy of hot spots in protein interfaces [J].

Bogan, AA ;

Thorn, KS .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 280 (01) :1-9

[5] The effect of size on the rate of an aminolysis reaction using a series of amine terminated PAMAM dendrimers [J].

Burnett, JL ;

King, ASH ;

Martin, IK ;

Twyman, LJ .

TETRAHEDRON LETTERS, 2002, 43 (13) :2431-2433

[6]

COPELAND RA, 1996, PRACTICAL INTRO STRU

[7]

FRANCESCA MO, 1997, J PHYS CHEM B, V101, P158

[8] A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets [J].

Huang, J ;

Schreiber, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13396-13401

[9] Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold [J].

Jain, RK ;

Hamilton, AD .

ORGANIC LETTERS, 2000, 2 (12) :1721-1723

[10] Principles of protein-protein interactions [J].

Jones, S ;

Thornton, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :13-20

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