Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms

被引：21

作者：

Singer, A ^{[1
]}

Bosselut, R ^{[1
]}

Bhandoola, A ^{[1
]}

机构：

[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

来源：

SEMINARS IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

thymus; T cell development; coreceptor; signaling;

D O I：

10.1006/smim.1999.0183

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A competent immune system requires that mature T cells express TCR and CD4/CD8 coreceptors with matching MHC specificities. Such matching of TCR and coreceptor specificity is induced in the thymus at the CD4(+)8(+) stage of development and is referred ed to as lineage commitment. The process by which immature CD4(+)8(+) thymocytes are signaled to undergo lineage commitment continues to be the subject of intense investigation and discussion. Here, we review the major models by which lineage commitment is thought to occur and discuss the experimental results on which they were based.

引用

收藏

页码：273 / 281

页数：9

相关论文

共 63 条

[1] DEFECTIVE T-CELL RECEPTOR SIGNALING AND CD8(+) THYMIC SELECTION IN HUMANS LACKING ZAP-70 KINASE [J].

ARPAIA, E ;

SHAHAR, M ;

DADI, H ;

COHEN, A ;

ROIFMAN, CM .

CELL, 1994, 76 (05) :947-958

[2] A HUMAN CD4 TRANSGENE RESCUES CD4-CD8+ CELLS IN BETA-2-MICROGLOBULIN-DEFICIENT MICE [J].

BARON, A ;

HAFEN, K ;

VONBOEHMER, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (08) :1933-1936

[3]

Basson MA, 1998, J EXP MED, V187, P1249

[4] CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection [J].

Benveniste, P ;

Knowles, G ;

Cohen, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (02) :461-471

[5] ANTIGEN MHC-SPECIFIC T-CELLS ARE PREFERENTIALLY EXPORTED FROM THE THYMUS IN THE PRESENCE OF THEIR MHC LIGAND [J].

BERG, LJ ;

PULLEN, AM ;

FAZEKAS DE ST GROTH, B ;

MATHIS, D ;

BENOIST, C ;

DAVIS, MM .

CELL, 1989, 58 (06) :1035-1046

[6] Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus [J].

Bommhardt, U ;

Cole, MS ;

Tso, JY ;

Zamoyska, R .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (05) :1152-1163

[7] DEVELOPMENT OF THE CD4 AND CD8 LINEAGE OF T-CELLS - INSTRUCTION VERSUS SELECTION [J].

BORGULYA, P ;

KISHI, H ;

MULLER, U ;

KIRBERG, J ;

VONBOEHMER, H .

EMBO JOURNAL, 1991, 10 (04) :913-918

[8] Visualization of CD4/CD8 T cell commitment [J].

Chan, S ;

Correia-Neves, M ;

Dierich, A ;

Benoist, C ;

Mathis, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2321-2333

[9] ROLE OF CORECEPTORS IN POSITIVE SELECTION AND LINEAGE COMMITMENT [J].

CHAN, SH ;

WALTZINGER, C ;

BARON, A ;

BENOIST, C ;

MATHIS, D .

EMBO JOURNAL, 1994, 13 (19) :4482-4489

[10] ANOTHER VIEW OF THE SELECTIVE MODEL OF THYMOCYTE SELECTION [J].

CHAN, SH ;

COSGROVE, D ;

WALTZINGER, C ;

BENOIST, C ;

MATHIS, D .

CELL, 1993, 73 (02) :225-236

← 1 2 3 4 5 6 7 →