A HUMAN CD4 TRANSGENE RESCUES CD4-CD8+ CELLS IN BETA-2-MICROGLOBULIN-DEFICIENT MICE

被引：36

作者：

BARON, A ^{[1
]}

HAFEN, K ^{[1
]}

VONBOEHMER, H ^{[1
]}

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 08期

关键词：

HUMAN CD4 TRANSGENIC MICE; BETA-2 MICROGLOBULIN-DEFICIENT MICE; CD4 VS CD8 LINEAGE COMMITMENT; INSTRUCTIVE VS SELECTIVE MODEL; THYMIC SELECTION;

D O I：

10.1002/eji.1830240834

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The specificity of the ap T cell receptor for class I or class II major histocompatibility complex (MHC) molecules determines whether a mature T cell will be of the CD4(-)CD8(+) or CD4(+)CD8(-) phenotype, respectively. We show here that a human CD4 transgene can rescue a significant fraction of CD4(-)CD8(+) T cells in beta 2-microglobulin-deficient mice. Cells with this phenotype could be induced to become potent killers of targets expressing allogeneic MHC antigens, indicating that lineage commitment can precede the rescue of developing cells by the T cell receptor for antigen and the CD4 coreceptor.

引用

页码：1933 / 1936

页数：4

共 27 条

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