How do we get a perfect complement of digits?

被引：23

作者：

Bastida, M. Felix ^{[2
]}

Ros, Marian A. ^{[1
]}

机构：

[1] CSIC UC IDICAN, Inst Biomed & Biotecnol Cantabria, IBBTEC, E-39011 Santander, Spain

[2] Univ Cantabria, Dept Anat & Biol Celular, E-39011 Santander, Spain

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.gde.2008.06.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

A crucial issue in limb development is how a correct set of precisely shaped digits forms in the digital plate. This process relies on patterning across the anterior-posterior axis of the limb bud, which is under the control of Sonic hedgehog emanating from the zone of polarizing activity. Recently, Sonic hedgehog function in the limb bud has been shown to have a dual character controlling both growth and patterning of the digital field. This finding has prompted the proposal of new models of how these two functions are achieved, and this will be discussed in this review.

引用

页码：374 / 380

页数：7

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