A systematic review of the use of atypical antipsychotics in autism

被引:76
作者
Barnard, L
Young, AH
Pearson, J
Geddes, J
O'Brien, G
机构
[1] Dev Psychiat Res Unit, Newcastle Upon Tyne, Tyne & Wear, England
[2] Univ Newcastle, Sch Neurosci & Psychiat, Stanley Fdn Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
[3] Univ Oxford, Warneford Hosp, Dept Psychiat, Ctr Evidence Based Mental Hlth, Oxford, England
[4] Northumbria Univ, Dev Psychiat Res Unit, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England
关键词
atypical antipsychotics; autistic disorder; learning disability; review; risperidone;
D O I
10.1177/026988110201600113
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Conventional antipsychotic medication is commonly prescribed to patients with autistic spectrum disorder. However, a high incidence of severe adverse reactions highlights the need to find more favourable treatments. Atypical antipsychotics may combine efficacy in ameliorating some autistic symptoms with a lower incidence of some adverse reactions. This article reviews: the use of atypical antipsychotics in autistic disorder, with particular focus on behaviour, cognition and physical well-being. Thirteen studies using risperidone, three using olanzapine, one using clozapine, one using amisulpride and one using quetiapine were identified. Few firm conclusions can be drawn due to the limitations of the studies; however, there is an indication that risperidone may be effective in reducing hyperactivity, aggression and repetitive behaviours, often without inducing severe adverse reactions. Olanzapine and clozapine may also be effective; however, there is little evidence for using amisulpride or quetiapine in this population. Randomized trials are required to clarify the effectiveness of these agents.
引用
收藏
页码:93 / 101
页数:9
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