Redox imbalance in the critically ill

被引:160
作者
Gutteridge, JMC
Mitchell, J
机构
[1] Royal Brompton & Harefield NHS Trust, Oxygen Chem Lab, Directorat Anaesthesia & Crit Care, London SW3 6NP, England
[2] Royal Brompton Hosp, Imperial Coll Med Sch, Unit Crit Care Med, London SW3 6LY, England
基金
英国惠康基金;
关键词
D O I
10.1258/0007142991902295
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The majority of deaths amongst critically ill patients requiring intensive care are attributable to sepsis and its sequelae: septic shock, the systemic inflammatory response syndrome (SIRS) and the acute respiratory distress syndrome (ARDS). Clinically, sepsis/SIRS and ARDS are characterised by disordered vascular control, manifest as systemic hypotension and peripheral vasodilation refractory to intravascular volume resuscitation and vasopressor therapy; and pulmonary hypertension. Experimental and clinical evidence demonstrates that these patients suffer from severe oxidative stress. Thus, our own and other groups have shown that the vascular pathology of sepsis/SIRS and ARDS is initiated through the uncontrolled production of reactive oxygen (ROS) and reactive nitrogen species (RNS) which modulate inflammatory cell adhesion and cause direct injury to endothelium (Fig. 1).
引用
收藏
页码:49 / 75
页数:27
相关论文
共 114 条
[31]  
GONZALEZ PK, 1995, J PHARMACOL EXP THER, V275, P798
[32]  
GROOTVELD M, 1989, J BIOL CHEM, V264, P4417
[33]  
Grum C.M., 1987, J. Crit. Care, V2, P22, DOI [10.1016/0883-9441(87)90116-X, DOI 10.1016/0883-9441(87)90116-X]
[34]  
Gutteridge J. M. C., 1994, ANTIOXIDANTS NUTR HL
[35]   CERULOPLASMIN - PHYSIOLOGICAL AND PATHOLOGICAL PERSPECTIVES [J].
GUTTERIDGE, JMC ;
STOCKS, J .
CRC CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 1981, 14 (04) :257-329
[36]   TRANSIENT IRON OVERLOAD WITH BLEOMYCIN DETECTABLE IRON IN THE PLASMA OF PATIENTS WITH ADULT-RESPIRATORY-DISTRESS-SYNDROME [J].
GUTTERIDGE, JMC ;
QUINLAN, GJ ;
EVANS, TW .
THORAX, 1994, 49 (07) :707-710
[37]   THE ANTIOXIDANT ACTIVITY OF HAPTOGLOBIN TOWARDS HEMOGLOBIN-STIMULATED LIPID-PEROXIDATION [J].
GUTTERIDGE, JMC .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 917 (02) :219-223
[38]   IRON PROMOTERS OF THE FENTON REACTION AND LIPID-PEROXIDATION CAN BE RELEASED FROM HEMOGLOBIN BY PEROXIDES [J].
GUTTERIDGE, JMC .
FEBS LETTERS, 1986, 201 (02) :291-295
[39]   INHIBITION OF LIPID-PEROXIDATION BY THE IRON-BINDING PROTEIN LACTOFERRIN [J].
GUTTERIDGE, JMC ;
PATERSON, SK ;
SEGAL, AW ;
HALLIWELL, B .
BIOCHEMICAL JOURNAL, 1981, 199 (01) :259-261
[40]   SUPEROXIDE-DEPENDENT FORMATION OF HYDROXYL RADICALS IN THE PRESENCE OF IRON SALTS - DETECTION OF FREE IRON IN BIOLOGICAL-SYSTEMS BY USING BLEOMYCIN-DEPENDENT DEGRADATION OF DNA [J].
GUTTERIDGE, JMC ;
ROWLEY, DA ;
HALLIWELL, B .
BIOCHEMICAL JOURNAL, 1981, 199 (01) :263-265