Prediction of mixture toxicity with its total hydrophobicity

被引：39

作者：

Lin, ZF ^{[1
]}

Yu, HX ^{[1
]}

Wei, DB ^{[1
]}

Wang, GH ^{[1
]}

Feng, JF ^{[1
]}

Wang, LS ^{[1
]}

机构：

[1] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resources Reuse, Nanjing 210093, Peoples R China

来源：

CHEMOSPHERE | 2002年 / 46卷 / 02期

基金：

中国国家自然科学基金;

关键词：

mixture toxicity; QSARs models; halogenated benzenes; partition coefficients of mixtures;

D O I：

10.1016/S0045-6535(01)00083-2

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Based on the C-18 Empore(TM) disk/water partition coefficient of a mixture, quantitative structure-activity relationships (QSARs) are presented, which are used to predict the toxicity of mixed halogenated benzenes to P. phosphoreum. The predicted toxicity of 10 other related mixtures based on the QSAR model, agree well with the observed data with r(2) = 0.973, SE = 0.113 and F = 287.785 at a level of significance P < 0.0001. The joint effect of these chemicals is simple similar action and the toxicity of the mixtures can be predicted from total hydrophobicity and is independent of hydrophobicity of the components or the ratio of the individual chemicals. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：305 / 310

页数：6

共 13 条

[1]

Hansch C, 1978, CORRELATION ANAL CHE, P397

[2]

Hansch C., 1979, Substituent constants for correlation analysis in chemistry and biology

[3] JOINT TOXICITY OF MIXTURES OF 8 AND 24 CHEMICALS TO THE GUPPY (POECILIA-RETICULATA) [J].