Cis-acting noncoding RNAs: friends and foes

被引：297

作者：

Guil, Sonia ^{[1
]}

Esteller, Manel ^{[1
,2
,3
]}

机构：

[1] Bellvitge Biomed Res Inst, Canc Epigenet & Biol Program, Barcelona, Catalonia, Spain

[2] Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Catalonia, Spain

[3] Inst Catalana Recerca & Estudis Avancats, Barcelona, Catalonia, Spain

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 11期

基金：

欧洲研究理事会;

关键词：

NATURAL ANTISENSE TRANSCRIPT; GENE-EXPRESSION; BIDIRECTIONAL PROMOTERS; POLYCOMB CBX7; CHROMATIN; GENOME; IDENTIFICATION; METHYLATION; MECHANISMS; ENHANCERS;

D O I：

10.1038/nsmb.2428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the number and types of known functional noncoding RNAs have increased considerably. A subset of both short- and long-sized species are known to be involved in the cis regulation of target genes located at or near the same genomic locus. Their expression is often coordinated with that of neighboring protein-coding genes, and in many cases, related transcripts can influence each other at one step or another during their biogenesis. Here, we review the current literature, summarizing the existing knowledge about mammalian cis-acting RNAs and their impact on physiological and disease states.

引用

页码：1068 / 1075

页数：8

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