Cis-acting noncoding RNAs: friends and foes

被引：297

作者：

Guil, Sonia ^{[1
]}

Esteller, Manel ^{[1
,2
,3
]}

机构：

[1] Bellvitge Biomed Res Inst, Canc Epigenet & Biol Program, Barcelona, Catalonia, Spain

[2] Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Catalonia, Spain

[3] Inst Catalana Recerca & Estudis Avancats, Barcelona, Catalonia, Spain

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 11期

基金：

欧洲研究理事会;

关键词：

NATURAL ANTISENSE TRANSCRIPT; GENE-EXPRESSION; BIDIRECTIONAL PROMOTERS; POLYCOMB CBX7; CHROMATIN; GENOME; IDENTIFICATION; METHYLATION; MECHANISMS; ENHANCERS;

D O I：

10.1038/nsmb.2428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the number and types of known functional noncoding RNAs have increased considerably. A subset of both short- and long-sized species are known to be involved in the cis regulation of target genes located at or near the same genomic locus. Their expression is often coordinated with that of neighboring protein-coding genes, and in many cases, related transcripts can influence each other at one step or another during their biogenesis. Here, we review the current literature, summarizing the existing knowledge about mammalian cis-acting RNAs and their impact on physiological and disease states.

引用

页码：1068 / 1075

页数：8

共 102 条

[21] The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator [J].

Feng, Jianchi ;

Bi, Chumming ;

Clark, Brian S. ;

Mady, Rina ;

Shah, Palak ;

Kohtz, Jhumku D. .

GENES & DEVELOPMENT, 2006, 20 (11) :1470-1484

[22] Genomic imprinting: the emergence of an epigenetic paradigm [J].

Ferguson-Smith, Anne C. .

NATURE REVIEWS GENETICS, 2011, 12 (08) :565-575

[23] Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome [J].

Flynn, Ryan A. ;

Almada, Albert E. ;

Zamudio, Jesse R. ;

Sharp, Phillip A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (26) :10460-10465

[24] Sense-antisense pairs in mammals: functional and evolutionary considerations [J].

Galante, Pedro A. F. ;

Vidal, Daniel O. ;

de Souza, Jorge E. ;

Camargo, Anamaria A. ;

de Souza, Sandro J. .

GENOME BIOLOGY, 2007, 8 (03)

[25] Polycomb CBX7 has a unifying role in cellular lifespan [J].

Gil, J ;

Bernard, D ;

Martínez, D ;

Beach, D .

NATURE CELL BIOLOGY, 2004, 6 (01) :67-U19

[26] Regulation of the INK4b-ARF-INK4a tumour suppressor locus:: all for one or one for all [J].

Gil, Jesus ;

Peters, Gordon .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (09) :667-677

[27] R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters [J].

Ginno, Paul A. ;

Lott, Paul L. ;

Christensen, Holly C. ;

Korf, Ian ;

Chedin, Frederic .

MOLECULAR CELL, 2012, 45 (06) :814-825

[28] Intronic RNAs mediate EZH2 regulation of epigenetic targets [J].

Guil, Sonia ;

Soler, Marta ;

Portela, Anna ;

Carrere, Jordi ;

Fonalleras, Elena ;

Gomez, Antonio ;

Villanueva, Alberto ;

Esteller, Manel .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (07) :664-+

[29] Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis [J].

Gupta, Rajnish A. ;

Shah, Nilay ;

Wang, Kevin C. ;

Kim, Jeewon ;

Horlings, Hugo M. ;

Wong, David J. ;

Tsai, Miao-Chih ;

Hung, Tiffany ;

Argani, Pedram ;

Rinn, John L. ;

Wang, Yulei ;

Brzoska, Pius ;

Kong, Benjamin ;

Li, Rui ;

West, Robert B. ;

van de Vijver, Marc J. ;

Sukumar, Saraswati ;

Chang, Howard Y. .

NATURE, 2010, 464 (7291) :1071-U148

[30] Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals [J].

Guttman, Mitchell ;

Amit, Ido ;

Garber, Manuel ;

French, Courtney ;

Lin, Michael F. ;

Feldser, David ;

Huarte, Maite ;

Zuk, Or ;

Carey, Bryce W. ;

Cassady, John P. ;

Cabili, Moran N. ;

Jaenisch, Rudolf ;

Mikkelsen, Tarjei S. ;

Jacks, Tyler ;

Hacohen, Nir ;

Bernstein, Bradley E. ;

Kellis, Manolis ;

Regev, Aviv ;

Rinn, John L. ;

Lander, Eric S. .

NATURE, 2009, 458 (7235) :223-227

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