The Fbxw7/hCdc4 tumor suppressor in human cancer

被引：91

作者：

Tan, YingMeei ^{[1
]}

Sangfelt, Olle ^{[2
]}

Spruck, Charles ^{[1
]}

机构：

[1] Sidney Kimmel Canc Ctr, Dept Tumor Cell Biol, San Diego, CA 92121 USA

[2] Karolinska Hosp, Canc Ctr Karolinska, S-10401 Stockholm, Sweden

来源：

CANCER LETTERS | 2008年 / 271卷 / 01期

基金：

瑞典研究理事会;

关键词：

Fbxw7; Ubiquitin ligase; Tumor suppressor; Cyclin E1; c-Myc;

D O I：

10.1016/j.canlet.2008.04.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fbxw7/hCdc4 is a member of the F-box family of proteins, which function as interchangeable substrate recognition components of the SCF ubiquitin ligases. SCFFbxw7/hCdc4 targets several important oncoproteins including c-Myc, c-Jun, cyclin El, and Notch, for ubiquitin-dependent proteolysis. Recent studies have shown that FBXW7/hCDC4 is mutated in a variety of human tumor types, suggesting that it is a general tumor suppressor in human cancer. Alteration of Fbxw7/hCdc4 function is linked to defects in differentiation, cellular proliferation, and genetic instability. In this review, we summarize what is known about Fbxw7/hCdc4-mediated degradation in the regulation of cellular proliferation and discuss how alteration of its function contributes to human tumorigenesis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 12

页数：12

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