The iterative synthesis of acyclic deoxypropionate units and their implication in polyketide-derived natural products

被引：75

作者：

Hanessian, S ^{[1
]}

Giroux, S ^{[1
]}

Mascitti, V ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

SYNTHESIS-STUTTGART | 2006年 / 7卷 / 07期

关键词：

natural products; enolates; conjugate additions; conformational analysis;

D O I：

10.1055/s-2006-926376

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Interest in natural products containing deoxypropionate units has recently grown since the emergence of powerful synthetic strategies to access syn and anti stereoarrays. The purpose of this review is to focus on iterative methodologies leading to enantiopure carbon chains harboring two or more contiguous deoxypropionate units. 1 Introduction 2 Chiral Auxiliary Mediated Methods 2.1 1,4-Conjugate Additions 2.2 Enolate and Azaenolate Alkylations 3 Asymmetric Allylic Substitution 4 Nonchiral Auxiliary Mediated Methods 4.1 Substrate and Conformational Control 4.2 Substrate and Reagent Directed Control 5 Indirect Methods 6 Catalytic Methods 6.1 Zr-Catalyzed Carboalumination Method 6.2 Catalytic Organocuprate Addition Method 7 Synopsis

引用

页码：1057 / 1076

页数：20

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