Phase diagrams of lipid mixtures relevant to the study of membrane rafts

被引：172

作者：

Goni, Felix M. ^{[1
,2
]}

Alonso, Alicia ^{[1
,2
]}

Bagatolli, Luis A. ^{[8
]}

Brown, Rhoderick E. ^{[3
]}

Marsh, Derek ^{[7
]}

Prieto, Manuel ^{[6
]}

Thewalt, Jenifer L. ^{[4
,5
]}

机构：

[1] Univ Basque Country, CSIC UPV EHU, Unidad Biofis, Ctr Mixto, E-48080 Bilbao, Spain

[2] Univ Basque Country, Dept Bioquim, E-48080 Bilbao, Spain

[3] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

[4] Simon Fraser Univ, Dept Phys, Burnaby, BC V5A 1S6, Canada

[5] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

[6] Inst Super Tecn, Ctr Quim Fis Mol, P-1049001 Lisbon, Portugal

[7] Max Planck Inst Biophys Chem, Spekt Abt, D-37070 Gottingen, Germany

[8] Univ So Denmark, Dept Biochem & Mol Biol, Ctr Biomembrane Phys, MEMPHYS, Odense, Denmark

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2008年 / 1781卷 / 11-12期

基金：

加拿大自然科学与工程研究理事会; 新加坡国家研究基金会;

关键词：

Membrane rafts; Lipid phase diagrams; Phosphatidylcholine; Sphingomyelin; Cholesterol;

D O I：

10.1016/j.bbalip.2008.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present paper reviews the phase properties of phosphatidylcholine-sphingomyelin-cholesterol mixtures, that are often used as models for membrane "raft" microdomains. The available data based on X-ray, microscopic and spectroscopic observations, surface pressure and calorimetric measurements, and detergent solubilization assays, are critically evaluated and rationalized in terms of triangular phase diagrams. The remaining uncertainties are discussed specifically and separately from the data on which a consensus appears to exist. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：665 / 684

页数：20

共 196 条

[11] Fluorescence probe partitioning between Lo/Ld phases in lipid membranes [J].