Bacteriophage Bionanowire as a Carrier for Both Cancer-Targeting Peptides and Photosensitizers and its use in Selective Cancer Cell Killing by Photodynamic Therapy

被引：95

作者：

Gandra, Naveen ^{[1
]}

Abbineni, Gopal ^{[1
]}

Qu, Xuewei ^{[1
]}

Huai, Yanyan ^{[1
]}

Wang, Li ^{[2
]}

Mao, Chuanbin ^{[1
]}

机构：

[1] Univ Oklahoma, Stephenson Life Sci Res Ctr, Dept Chem & Biochem, Norman, OK 73019 USA

[2] NE Normal Univ, Sch Life Sci, Changchun, Jilin, Peoples R China

来源：

SMALL | 2013年 / 9卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会; 中国国家自然科学基金;

关键词：

bionanowires; photodynamic therapy; photosensitizers; bioconjugation; BIOLOGICAL NANOFIBERS; MAJOR COAT; PHAGE; DISPLAY; VECTORS; WATER; MINERALIZATION; EFFICIENCY; RADIATION; DELIVERY;

D O I：

10.1002/smll.201202090

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A photosensitizer, pyropheophorbid-a (PPa), is conjugated to SKBR-3 breast cancer cell-specific biological nanowire phage, to form a novel PPa-phage complex, which is further successfully used in selectively killing SKBR-3 breast cancer cells by the mechanism of photodynamic therapy (PDT). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：215 / 221

页数：7

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