Extracellular vesicles: biology and emerging therapeutic opportunities

被引：2685

作者：

EL Andaloussi, Samir ^{[1
,3
]}

Maeger, Imre ^{[1
,4
]}

Breakefield, Xandra O. ^{[2
]}

Wood, Matthew J. A. ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

[2] Massachusetts Gen Hosp, Neurogenet Unit, Charlestown, MA USA

[3] Karolinska Inst, Dept Lab Med, SE-14186 Solna, Sweden

[4] Univ Tartu, Inst Technol, EE-50411 Tartu, Estonia

来源：

NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 05期

基金：

英国医学研究理事会;

关键词：

TUMOR-DERIVED MICROVESICLES; MESENCHYMAL STEM-CELL; PROGENITOR CELLS; DENDRITIC CELLS; MULTIVESICULAR BODIES; HORIZONTAL TRANSFER; EXOSOME SECRETION; INDUCE APOPTOSIS; PLASMA-MEMBRANE; MESSENGER-RNAS;

D O I：

10.1038/nrd3978

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macro-molecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.

引用

页码：348 / 358

页数：11

共 120 条

[1] Microvesicle-mediated RNA Molecule Delivery System Using Monocytes/Macrophages [J].

Akao, Yukihiro ;

Iio, Akio ;

Itoh, Tomohiro ;

Noguchi, Shunsuke ;

Itoh, Yuko ;

Ohtsuki, Yoshinori ;

Naoe, Tomoki .

MOLECULAR THERAPY, 2011, 19 (02) :395-399

[2] Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Micallef, Johann ;

Lhotak, Vladimir ;

May, Linda ;

Guha, Abhijit ;

Rak, Janusz .

NATURE CELL BIOLOGY, 2008, 10 (05) :619-U24

[3] Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Kerbel, Robert S. ;

Allison, Anthony C. ;

Rak, Janusz .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) :3794-3799

[4] Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: A novel mechanism for phenotype modulation [J].

Aliotta, Jason M. ;

Sanchez-Guijo, Fermin M. ;

Dooner, Gerri J. ;

Johnson, Kevin W. ;

Dooner, Mark S. ;

Greer, Kenneth A. ;

Greer, Deborah ;

Pimentel, Jeffrey ;

Kolankiewicz, Lutz M. ;

Puente, Napoleon ;

Faradyan, Sam ;

Ferland, Paulette ;

Bearer, Elaine L. ;

Passero, Michael A. ;

Adedi, Mehrdad ;

Colvin, Geralt A. ;

Quesenberry, Peter J. .

STEM CELLS, 2007, 25 (09) :2245-2256

[5] Stable cell fate changes in marrow cells induced by lung-derived microvesicles [J].

Aliotta, Jason M. ;

Pereira, Mandy ;

Li, Ming ;

Amaral, Ashley ;

Sorokina, Arina ;

Dooner, Mark S. ;

Sears, Edmund H. ;

Brilliant, Kate ;

Ramratnam, Bharat ;

Hixson, Douglas C. ;

Quesenberry, Peter J. .

JOURNAL OF EXTRACELLULAR VESICLES, 2012, 1 (01)

[6] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[7] Syndecan-syntenin-ALIX regulates the biogenesis of exosomes [J].

Baietti, Maria Francesca ;

Zhang, Zhe ;

Mortier, Eva ;

Melchior, Aurelie ;

Degeest, Gisele ;

Geeraerts, Annelies ;

Ivarsson, Ylva ;

Depoortere, Fabienne ;

Coomans, Christien ;

Vermeiren, Elke ;

Zimmermann, Pascale ;

David, Guido .

NATURE CELL BIOLOGY, 2012, 14 (07) :677-685

[8] Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes [J].

Baj-Krzyworzeka, M ;

Szatanek, R ;

Weglarczyk, K ;

Baran, J ;

Urbanowicz, B ;

Branski, P ;

Ratajczak, MZ ;

Zembala, M .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2006, 55 (07) :808-818

[9] Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells [J].

Baj-Krzyworzeka, M ;

Majka, M ;

Pratico, D ;

Ratajczak, J ;

Vilaire, G ;

Kijowski, J ;

Reca, R ;

Janowska-Wieczorek, A ;

Ratajczak, MZ .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (05) :450-459

[10] Tumour-derived microvesicles modulate biological activity of human monocytes [J].

Baj-Krzyworzeka, Monika ;

Szatanek, Rafal ;

Weglarczyk, Kazimierz ;

Baran, Jaroslaw ;

Zembala, Marek .

IMMUNOLOGY LETTERS, 2007, 113 (02) :76-82

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