Extracellular vesicles: biology and emerging therapeutic opportunities

被引：2606

作者：

EL Andaloussi, Samir ^{[1
,3
]}

Maeger, Imre ^{[1
,4
]}

Breakefield, Xandra O. ^{[2
]}

Wood, Matthew J. A. ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

[2] Massachusetts Gen Hosp, Neurogenet Unit, Charlestown, MA USA

[3] Karolinska Inst, Dept Lab Med, SE-14186 Solna, Sweden

[4] Univ Tartu, Inst Technol, EE-50411 Tartu, Estonia

来源：

NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 05期

基金：

英国医学研究理事会;

关键词：

TUMOR-DERIVED MICROVESICLES; MESENCHYMAL STEM-CELL; PROGENITOR CELLS; DENDRITIC CELLS; MULTIVESICULAR BODIES; HORIZONTAL TRANSFER; EXOSOME SECRETION; INDUCE APOPTOSIS; PLASMA-MEMBRANE; MESSENGER-RNAS;

D O I：

10.1038/nrd3978

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macro-molecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.

引用

页码：348 / 358

页数：11

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