Perfluoroalkylation of 6-iodopurines by trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(perfluoroalkyl)purine bases, nucleosides and acyclic nucleotide analogues

被引：36

作者：

Hocek, M ^{[1
]}

Holy, A ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1999年 / 64卷 / 02期

关键词：

purines; nucleosides; cross-coupling reactions; trifluoromethylation; perfluoroalkylation; cuprates; fluorinated compounds; cytostatic activity;

D O I：

10.1135/cccc19990229

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A CuI/KF mediated perfluoroalkylation reaction of various 9-substituted 6-iodopurines 1 with trimethyl(trifluoromethyl)silane or heptafluoropropyl(trimethyl)silane was used for the synthesis of the corresponding 6-(trifluoromethyl)- and 6-(heptafluoropropyl)purine derivatives (purine bases, nucleosides and acyclic nucleotide analogues) in moderate to good yields.

引用

页码：229 / 241

页数：13

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